Keywords

• 100% Safe Delivery FG-4592
• Low price FG-4592
• High quality FG-4592

Quick Details

• ProName: Free Sample CAS 808118-40-3
• CasNo: 808118-40-3
• Molecular Formula: C19H16N2O5
• Appearance: White powder
• Application: Roxadustat (FG-4592) is an oral prolyl...
• DeliveryTime: 3-5days
• PackAge: Barreled
• Port: shanghai
• ProductionCapacity: 5000 Metric Ton/Year
• Purity: 99%
• Storage: 2-8°C
• Transportation: 2-8°C
• LimitNum: 10 Kilogram
• Moisture Content: No
• Impurity: No
• Place of Origin: China

Superiority

Details

Physicochemical properties
Density: 1.4±0.1 g/cm3
Boiling point: 684.3±55.0 °C at 760 mmHg
Molecular formula: C19H16N2O5
Molecular weight: 352.341
Flash point: 367.6±31.5 °C
Exact quality: 352.105927
PSA: 108.75000
LogP: 3.90
Vapor pressure: 0.0±2.2 mmHg at 25°C
Refractive index: 1.674

Function
Roxadustat (FG-4592) is an oral prolyl hydroxylase HIF inhibitor developed for the treatment of anemia.

Pharmacological action
Roxastat is a 4-hydroxyisoquinoline derivative, a small molecule HIF-PH enzyme inhibitor. HIF is an important transcription factor that adapts to oxygen changes in the body. Under normal oxygen conditions, HIF-PH enzyme will promote HIF degradation; when the body is hypoxia, the chemicalbook activity of HIF-PH enzyme is inhibited, and the accumulation of HIF increases, thereby inducing The corresponding gene expression makes the body adapt to changes in hypoxia. Roxastat inhibits the activity of HIF-PH enzyme under the condition that the body is not hypoxic, increases the accumulation of HIF, and then produces corresponding physiological reactions.