Keywords

• Neurontin
• Gabapetin
• Gabapentin HCl

Quick Details

• ProName: Superior quality Gabapentin
• CasNo: 60142-96-3
• Molecular Formula: C9H17NO2
• Appearance: White Powder
• Application: Personal Care/Cosmetic Pharmaceutical....
• DeliveryTime: 15days
• PackAge: 1kg/bag,25kg/drum,or as your requireme...
• Port: Shanghai
• ProductionCapacity: 2000 Metric Ton/Month
• Purity: 99%
• Storage: Cool Dried Storage
• Transportation: by sea or by air
• LimitNum: 5 Gram
• Heavy metal: N/A
• Grade: Industrial Grade,Food Grade,Pharma Gra...
• EINECS No.: 262-076-3
• Place of Origin: China
• Brand Name: Shuokang

Superiority

 Company Profile 

    ShuoKang biotechnology co., LTD. Is located in wuhan, China, is a collection research and development, production, sales for the integration of medicine and chemical industry leader, the company has been to high-quality products and services to Chinese and foreign customers.

Our advantages

1.  High high quality with competitive price:   
2. Fast and safe delivery
3. We have clients throughout the world.

• standard:bp/usp/ep/enterprise standard
• all purity≥99%

Details

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Application                                                                                                                                                                     Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.IC50 Value: 140 nM (α2δ subunit of calcium channel) [1]Target: Calcium Channelin vitro: Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively). Gabapentin was without effect on the release of [3H]GABA, whilst baclofen (IC50=8 microM) and CGP 44532 (IC50=1 microM) inhibited [3H]GABA release [2]. A large inhibition of calcium currents by gabapentin was observed in pyramidal neocortical cells (up to 34%). Significantly, the gabapentin-mediated inhibition of calcium currents saturated at particularly low concentrations (around 10 microM), at least in neocortical neurons (IC50 about 4 microM) [3].in vivo: Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-α, 316.0 ± 69.7 pg/mL vs 88.8 ± 24.4 pg/mL; IL-1β, 1,212.9 ± 104.5 vs 577.4 ± 97.1 pg/mL; IL-6, 254.0 ± 64.8 pg/mL vs 125.5 ± 44.1 pg/mL; IL-10, 532.1 ± 78.7 pg/mL vs 918.9 ± 63.1 pg/mL). The suppressive effect of gabapentin on pro-inflammatory cytokine expression was partially blocked by the anti-IL-10 antibody [4].Toxicity: No new safety signals or adverse event trends relating to GEn exposure were identified [5].Clinical trial: N/A