Wuhan Shuokang Biological Technology Co.，Ltd(expird)
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CAS NO.68786-66-3
Top grade(1-20)Metric TonTop grade(1-50)Metric Ton
| Description | Triclabendazole(CGA89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.Target: Microtubule/TubulinTriclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm [1]. Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines [2].Triclabendazole is metabolized into a number of compounds, depending on the route of administration, plasma levels peak at 18-24 hours (Triclabendazole sulphoxide) and 36-48 hours (Triclabendazole sulphone), neither Triclabendazole nor any toher metabolites can be detected in plasma. Triclabendazole sulphoxide blocks the transport of secretory bodies from the cell body to the tegumental surface, the block occurs at the site of their formation by the Golgi complex in the cell body, in their movement through the cytoplasmic connections to the syncytium, and in their movement from the base to the apex of the syncytium. Triclabendazole binds to the colchicine binding site on the β-tubulin molecule and this has been used at the basis for evaluating the relative acitvity of Triclabendazole [3]. |
|---|---|
| Related Catalog |
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Infection |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 495.9±55.0 °C at 760 mmHg |
| Melting Point | 175-176°C |
| Molecular Formula | C14H9Cl3N2OS |
| Molecular Weight | 359.658 |
| Flash Point | 253.7±31.5 °C |
| Exact Mass | 357.950104 |
| PSA | 63.21000 |
| LogP | 5.97 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.724 |
| Stability | Stability |
Company Profile
Wuhan Shuokang biological Technology Co., Ltd. is a professional chemical company， located in Wu Han city, Hubei Province, China. We are in the production, sales and supply pharmaceutical intermediates. In the past years, our products have spread over more 50 countries in the world. Most of products produced and sold are exported abroad, and it’s well-received in all around the world for its excellent quality. Our goal is to survive by quality and develop by credit.
In the past two years, our products have spread over more than 30 countries in the world, Europe, South America, North America,Southeast Asia and Africa. We work with friends all over the world to develop the best quality products, the most reasonable price, safe and effective transportation.
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FAQ
Q1: Are you a manufacturer
Answer: Yes, we are factory founded on 2011.
Q2: How to contact with us
Click the "Contact Supplier" And then send us message the product you interest in, you will get valid reply within TWO hours.
Q3:Which kind of payment terms do you accept
For small order,you can pay by T/T, or Paypal,nomal order by T/T to our company account
Q4:Can you give me a discount price
Sure,It depends on your qty.
Q5:How can i get a sample
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your
order in the future.
Q6: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the
samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q7:How do you treat quality complaint
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,
we will send you free goods for replacement or refund your loss.